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Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (4): 863.

• Articles • Previous Articles     Next Articles

Interaction Between N-Benzoyl\|dehydroabietylamine Derivatives with Angiotensin Ⅲ by Electrospray  Ionization Mass Spectrometry

LÜ Lin1, DENG Hui-Min1*, LIN Zhong-Xiang2   

  1. 1. Instrumental Analysis Research Center, Sun Yat\|sen University, Guangzhou 510275, China;
    2. College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
  • Received:2010-06-08 Revised:2010-09-22 Online:2011-04-10 Published:2011-03-09
  • Contact: DENG Hui-Min E-mail:denghm@mail.sysu.edu.cn
  • Supported by:

    国家自然科学基金(批准号:  30771688,  30871989)资助.

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Abstract: The interactions between the novel N-benzoyl-dehydroabietylamine derivatives（NBDD）including N-benzoyl-dehydroabietylamine(NBD),N-o-chlorobenzoyl-benzoyl–dehydroabietyl- amine(NClBD),N-benzoyl-dehydroabietylamine-7-one(NBDO),N-o-chlorobenzoyl–dehydroabi- etylamine-7-one(NClBDO) with Angiotensin Ⅲ were investigated by electrospray ionization mass spectrometry (ESI-MS). The results showed that the four derivatives all could form non-covalent complexes with Ang Ⅲ when the derivatives mixed with Ang Ⅲ in molar ratio of NBDD:AngⅢ 1:1, 3:1,5:1, and the complexes mainly formed +2 charged ions. The MS2 of [NBDD-AngⅢ+2H]2+ and MS2 and MS3 of [(NBDD)2-AngⅢ+2H]2+ were studied．The stability of four kinds of complexes [NBDD-AngⅢ+2H]2+ and the combination mode of NBDD with Ang Ⅲ were discussed.

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