Abstract: HP136 is a free radical scavenging anti-oxidant invented by Ciba Specialty Chemicals,  which is widely used in the process of polyolefin production. However,  recently it has receded from the market probably because of its potential toxicity to human bodies. In order to develop a novel anti-oxidant with both high effectivity and low toxicity,  a series of HP136 derivatives were synthesized. The melt flow indexes and yellowness indexes showed that the anti-oxidant ability and color change of 1,1-diaryl-acetamides were both similar with HP136. Among them,  2-(3,5-di-tert-butyl-2-hydroxyphenyl)-N-allyl-2-phenyl acetamide(2d) had an anti-oxidant activity as high as HP136. We believe that it will have a prosperous future for application in the industry.