Design, Synthesis and Antifungal Activity Against Valsa Mali of the Triamino Substitued Triazines Bearing Aminopyrimidine Group

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (12): 2795.

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Design, Synthesis and Antifungal Activity Against Valsa Mali of the Triamino Substitued Triazines Bearing Aminopyrimidine Group

ZHAO Lian¹, YUAN Xiang-Guo¹, ZHAO Jian-Peng¹, CHEN Hua^1*, LIU Li², LI Xiao-Liu¹, CAO Ke-Qiang²

1. Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China;
2. College of Plant Protection, Hebei Agricultural University, Baoding 071001, China

Received:2011-01-17 Revised:2011-03-17 Online:2011-12-10 Published:2011-11-25
Contact: CHEN Hua E-mail:hua-todd@163.com
Supported by:
国家自然科学基金(批准号: 20902016)和河北省科学技术研究与发展计划项目(批准号: 09276418D-13)资助.

Abstract

Abstract: In order to find novel plant fungicides targeting Valsa mali with high activity, fifteen triamino substituted 1,3,5-triazine compounds bearing 2-amino-4,6-dimethyl-5-(un) substituted pyrimidine were designed according to the antifungal characteristics of triazine and pyrimidine and the superposition principle of reinforcement of biological activity. These compounds were synthesized by amino substitution using cyanuric chloride as the starting material, and their structures were characterized and determined by 1H NMR, ESI-MS and elemental analysis. The antifungal activity against Valsa mali of the new compounds were evaluated and the results showed that a majority of the compounds have notable inhibitory activity against Valsa mali. For examples, at the concentration of 200 μg/mL, compounds 2aa, 2ba, 2ca, 2da, 3ba and 3ea have the inhibition rate of 96.33%, 98.17%, 97.25%, 97.71%, 98.39% and 94.50%, respectively, and have the inhibition rates above 74% at the concentration of 100 μg/mL, which suggest that such triamino substituted triazine compounds have the potential applications in further development for new fungicides.

Key words: Aminopyrimidine, Triazine, Antifungal activity, Valsa mali

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ZHAO Lian, YUAN Xiang-Guo, ZHAO Jian-Peng, CHEN Hua*, LIU Li, LI Xiao-Liu, CAO Ke-Qiang. Design, Synthesis and Antifungal Activity Against Valsa Mali of the Triamino Substitued Triazines Bearing Aminopyrimidine Group[J]. Chem. J. Chinese Universities, 2011, 32(12): 2795.

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Design, Synthesis and Antifungal Activity Against Valsa Mali of the Triamino Substitued Triazines Bearing Aminopyrimidine Group

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