Preparation of New  Poly(α-D-galactopyranose) Chain-grafted Silica Chromatographic Stationary Phase by Atom Transfer Radical Polymerization and Its Chromatographic Properties

Chem. J. Chinese Universities ›› 2011, Vol. 32 ›› Issue (12): 2757.

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Preparation of New Poly(α-D-galactopyranose) Chain-grafted Silica Chromatographic Stationary Phase by Atom Transfer Radical Polymerization and Its Chromatographic Properties

WANG Fu-Qiang, HAO Jun-Xia, DAI Xiao-Jun, GONG Bo-Lin*

Key Laboratory of Energy & Chemical Engineering, Ningxia University, Yinchuan 750021, China

Received:2011-04-07 Revised:2011-06-23 Online:2011-12-10 Published:2011-11-25
Contact: GONG Bo-Lin E-mail:gongbl@nxu.edu.cn
Supported by:
科技部重大基础研究前期专项(批准号: 2009CB626608)、国家自然科学基金(批准号: 201065008)和宁夏自然科学基金项目(批准号: NZ0838)资助.

Abstract

Abstract: Atom transfer radical polymerization(ATRP) of α-D-galactopyranose was conducted on the surface of 5 μm silicas at ambient temperature using 2-bromoisobutryl bromide as the initiator and CuCl/CuCl2/tris[2-(dimethylamino)ethyl]amine(Me6TREN) as the catalytic system, a novel pMAIPGal chromatographic stationary phase was obtained. The synthesized stationary phase was evaluated in detail to determine its separability, monomer synthetical process, effect of acetonitrile(ACN) and methanol on the retention of solutes. The stationary phase was characterized by means of element analysis and FTIR spectroscopy. The amount of monomer was calculated to be 0.818 mg/m2 on the surface of silica, and the stationary phase can effectively separated seven hydroxybenzene compounds and four amine compounds in reverse phase liquid chromatography(RPLC) mode. Compared with C18 column for separation of these compounds under the same chromatographic conditions, the separation efficiency was better, and the analysis time was shortened. The organic solvent content in the mobile phase has the largest influence on the retention of hydroxybenzene and amine compounds, the retention factor decreased along with increasing the organic solvent content in the mobile phase. The results show that the synthesized stationary phase has satisfactory chromatographic properties.

Key words: Atom transfer radical polymerization(ATRP), Poly(α-D-galactopyranose), Chromatographic stationary phase, Separation of hydroxybenzene and amine compounds, Chromatographic property

CLC Number:

O657

TrendMD:

WANG Fu-Qiang, HAO Jun-Xia, DAI Xiao-Jun, GONG Bo-Lin*. Preparation of New Poly(α-D-galactopyranose) Chain-grafted Silica Chromatographic Stationary Phase by Atom Transfer Radical Polymerization and Its Chromatographic Properties[J]. Chem. J. Chinese Universities, 2011, 32(12): 2757.

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Preparation of New Poly(α-D-galactopyranose) Chain-grafted Silica Chromatographic Stationary Phase by Atom Transfer Radical Polymerization and Its Chromatographic Properties

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