FTIR Spectroscopic Study on Brain Tumors

Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (9): 1717.

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FTIR Spectroscopic Study on Brain Tumors

PAN Qing-Hua^1,3, WAN Wei-Qing², JIA Gui-Jun², XU Yi-Zhuang^1*, LAI Guo-Qiao³, LIU Shao-Xuan¹, CHEN Jing¹, YANG Li-Min¹, ZHANG Yuan-Fu¹, WENG Shi-Fu¹, WU Jin-Guang¹

1. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
2. Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100083, China;
3. Key Laboratory of Organosilicon Chemistry and Material Technology, Hangzhou Teachers College, Hangzhou 310012, China)

Received:2010-03-31 Online:2010-09-10 Published:2010-09-10
Contact: XU Yi-Zhuang. E-mail: xyz@pku.edu.cn
Supported by:
国家自然科学基金(批准号: 30371604, 50203001, 20171004)资助.

Abstract

Abstract: In the present investigation, 28 patients with brain tumor were recruited for FTIR spectroscopic measurement. These obtained FTIR spectra were analyzed and compared. It was found that there were significant differences in the spectral features of neurinoma and tumours of neuroepithelial tissue(e.g. astrocytoma) such as the changes in peak position, band shape and relative intensity of the bands including the main indexes I_{1460 cm-1}/I_{1400 cm-1}, I_{1160 cm-1}/I_{1120 cm-1} and I_{1160 cm-1}/I_{1080 cm-1} in the ranges of 1000—1800 cm^-1. The similar differences in the spectral features of the residue of the brain tumor was found. The results show that the relative intensity of the bands(such as I_{1460 cm-1}/I_{1400 cm-1}, I_{1160 cm-1}/I_{1120 cm-1} and I_{1160 cm-1}/I_{1080 cm-1}) can be used to distinguish neurinoma from tumours of neuroepithelial tissue(such as astrocytoma) which are in agreement with the pathological results larger than 85%.

Key words: FT-mid-IR, Attenuate total reflection, Brain tumor

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PAN Qing-Hua, WAN Wei-Qing, JIA Gui-Jun, XU Yi-Zhuang*, LAI Guo-Qiao, .... FTIR Spectroscopic Study on Brain Tumors[J]. Chem. J. Chinese Universities, 2010, 31(9): 1717.

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FTIR Spectroscopic Study on Brain Tumors

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