Synthesis and Self-assembly Behavior of a Novel Amphiphilic Block Glycopolymer

Abstract

Abstract: A novel amphiphilic block polymers based on peracetylated maltoheptaose and poly(2-ethyl-2-oxazoline)(AcMH-b-PEtOz) was synthesized by endcapping reaction. Their structures were confirmed by the combined analyses from hydrogen nuclear magnetic resonance(¹H NMR), gel permeation chromatograph(GPC) and Fourier transform infrared spectrometry(FTIR). Their micellar formation and characteristics in an aqueous phase were investigated by means of ¹H NMR, fluorescence spectrum, transmission electron microscopy(TEM), dynamic light scattering(DLS) and UV-Visible spectrum. It was found that the obtained block polymers could self-assemble into nanosize spherical micelles with a core-shell structure in aqueous solution triggered by its amphiphilic character without any organic solvent and exhibited thermal sensitivity. The critical micelle concentration(cmc) of the micelles ranged from 4 to 7 mg/L with mean diameters in the range of 83—115 nm and lower critical solution temperatures(LCST) in the range of 49—64 ℃. The cmc, size and thermal sensitivity of the self-assembled micelles could be tailored by changing the PEtOz content of the resultant block polymer.

Key words: Amphiphilic block copolymer, Glycopolymer, Poly(2-ethyl-2-oxazoline), Self-assembly, Thermo-sensitive

TrendMD:

CHEN Li-Qiong, ZHANG Li-Ming*, CHEN Jian-Jun, YANG Jian, LI Rong-Xian. Synthesis and Self-assembly Behavior of a Novel Amphiphilic Block Glycopolymer[J]. Chem. J. Chinese Universities, 2010, 31(8): 1676.

References

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