Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (7): 1456.

• Articles • Previous Articles     Next Articles

Synthesis and Property of an Amphiphilic Polymer Containing Nucleobases and Aza-crown Ethers

ZHANG Yu-Jian, HE Zhen-Feng, LI Guo-Wen*   

  1. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China
  • Received:2009-10-12 Online:2010-07-10 Published:2010-07-10
  • Contact: LI Guo-Wen. E-mail: lgw@jlu.edu.cn
  • Supported by:

    国家自然科学基金(批准号: 20874037, 20674025)资助.

Abstract:

An amphiphilic polymer containing thymine and aza-crown ethers, poly-{[N,N-bis(2-ethoxy)-1,10-diaza-18-crown-6][5-methylene-(1-thymine)] sophthaloyl ester}(PCTSE), was synthesized. The SEM morphology observed via indicates that the amphiphilic PCTSE polymer self-organized into diameters of about 150—220 nm nanospheres in dilute aqueous solution spontaneously. The sizes of PCTSE nanospheres in dilute aqueous solution determined by DLS are mainly dispersed at 130—240 nm. The molecule recognition based on hydrogen bond between thymine of polymer and adenine substrate in PCTSE/adenine nanospheres was stu-died. After recognition the C4=O stretching vibration at 1670 cm-1 of thymine of polymer shifted to 1664 cm-1, which implied the formation of hydrogen bonds between thymine and adenine. The study on variable temperature FTIR show that the peak gradually shifted back to the position at 1670 cm-1, which indicates that the H-bond was broken.

Key words: Amphiphilic polymer; Aza-crown ether; Nucleobase; Nanosphere; Molecular recognition

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