Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (7): 1365.

• Articles • Previous Articles     Next Articles

Synthesis of 1-Acetyl-3-(2-hydroxyl-4,6-dimethoxylphenyl)-5-phenyl-2-pyrazoline and Studies on Its Zinc Ion Probe

YANG An-Bo1, XU Zhu-Xiong1, WU Jing1, FENG Yu-Ying2, WANG Bing-Xiang1*   

  1. 1. Key Laboratory of Biofunctional Materials of Jiangsu Province, Research Center of Biomedical Functional Materials Engineering of Jiangsu Province, College of Chemistry and Environmental Science,
    2. Analysis and Test Center, Nanjing Normal University, Nanjing 210097, China
  • Received:2009-10-20 Online:2010-07-10 Published:2010-07-10
  • Contact: WANG Bing-Xiang. E-mail: wangbingxiang@njnu.edu.cn
  • Supported by:

    江苏省自然科学基金(批准号: BK2008435)和江苏省科技重大项目-江苏省生物医药材料测试服务平台项目(批准号: BM2007132)资助.

Abstract:

The development of Zn2+ ion chemosensors has received considerable attention. The use of Zn2+-specific chemosensors in biological systems promises to close the knowledge gap between the well-defined structural biochemistry of zinc and the understanding of zinc homeostasis and action. The synthesis of 1-acetyl-3-(2-hydroxy-4,6-dimethoxy-phenyl)-5-phenyl-2-pyrazoline(4) and the studies of it as fluorescent sensors for Zn2+ ion were reported. Its UV-Vis and fluorescence spectrum were detected. The influences of 14 metal ions such as Cu2+, Zn2+, Co2+ etc. on their fluorescence properties were measured. Spectroscopic studies revealed that the compound 4 had rather strong affinity toward zinc ion. The specificity of the probe 4 toward Zn2+ was determined. Nearly no fluorescence intensity changes were observed in emission spectra with Cu2+, Co2+, Ni2+, Na+, K+, Ca2+, Cr3+, Cd2+, Al3+, Mn2+, Pb2+, Sr2+ and Sn2+. However, under identical conditions, fluorescence intensity enhanced significantly in the presence of Zn2+. So we have developed a new fluorescent sensor(compound 4). It show high sensitivity and selectivity toward Zn2+ in DMSO aqueous solution.

Key words: 1-Acetyl-3-(2-hydroxy-4,6-dimethoxy-phenyl)-5-phenyl-2-pyrazoline; Zinc ion; Fluorescence probe

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