Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (6): 1075.

• Letters • Previous Articles     Next Articles

Novel Two-photon Fluorescent Probe 2,7-BHVC for DNA Imaging

JIA Peng-Fei1, LIU Heng1*, ZHANG Yuan-Hong2, LIU Xin2, ZHAO Ning2, YU Xiao-Qiang2*   

  1. 1. School of Life Science, Lanzhou University, Lanzhou 730000, China;
    2. State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China
  • Received:2010-01-18 Online:2010-06-10 Published:2010-06-10
  • Contact: LIU Heng. E-mail: hengliu@lzu.edu.cn; YU Xiao-Qiang. E-mail: yuxq@sdu.edu.cn
  • Supported by:

    国家自然科学基金(批准号: 50673053)和教育部博士点基金(批准号: 200807300014)资助.

Abstract:

2,7-BHVC, a novel two-photon fluorescent probe for DNA with large two-photon excited fluorescence action cross sections, was synthesized and characterized. It emits weak two-photon fluorescence in aqueous solution while its two-photon fluorescence is strongly restored upon binding to DNA. The two-photon imaging in cell demonstrated that 2,7-BHVC can exactly label nuclear DNA.

Key words: Two-photon fluorescent probe; Two-photon fluorescence imaging; DNA

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