Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (5): 982.

• Articles • Previous Articles     Next Articles

Preparation of Gd/Quantum Dots Multimodal Imaging Probes for Disease Diagnosis

ZHANG Bing-Bo1, GONG Xiao-Qun2, LI Zhuo-Quan1, GUO Fang-Fang1, CAI Shao-Yu5, KONG Ji-Lie5, YANG Qiu-Hua2, MA Hao2, CHANG Jin1,2, SHI Dong-Lu1,3,4*   

  1. 1. Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai, 200092 China;
    2. Institute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China;
    3. Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati OH 45221-0012, USA;
    4. Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China;
    5. Department of Chemistry, Fudan University, Shanghai 200433, China
  • Received:2009-10-23 Online:2010-05-10 Published:2010-05-10
  • Contact: SHI Dong-Lu. E-mail: shid@ucmail.uc.edu
  • Supported by:

    国家自然科学基金(批准号: 50873076)、国家“八六三”重点项目(批准号: 2007AA021808)、上海纳米专项(批准号: 0952nm04800, 0852nm03800)和同济大学青年优秀人才培养计划(批准号: 2009KJ072)资助.

Abstract:

One of the major challenges in tumor research is early diagnosis in vivo. The current diagnostic methods, such as PET, MRI, and hematology tests, although effective in some aspects of tumor observations, are limited as a result of single functionality. Furthermore, the detection mechanism is often not compatible with the imaging system, making it difficult for accurate diagnosis. In this paper, MRI and fluorescence imaging were combined with several key contrast agents including quantum dots(QDs), gadolinium ion, silica, and poly(acrylic acid)(PAA) for high relaxation rate, strong fluorescent emission, and good biocompatibility, among which Gd/QDs were utilized for effective multimodal nano-probes. The experimental results from this study indicate a higher relaxation rate of the Gd/QDs multimodal nano-probes than that of silica-coated QDs without Gd. The t1-weighted MRI analysis show that these Gd/QDs based nano-probes can be potentially used for effective multimodal imaging agents.

Key words: Multimodal imaging; Near infrared quantum dots; Magnetic resonance image(MRI)

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