Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (2): 413.

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Preparation and Characterization of pH-Sensitive Polyorganophosphazene Hydrogel

HONG Ting, LIU Zhi-Ling, ZHOU Yuan-Yuan, CAI Qing*, JIN Ri-Guang   

  1. Key Laboratory of Beijing City on Preparation and Processing & Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, China
  • Received:2009-04-21 Online:2010-02-10 Published:2010-02-10
  • Contact: CAI Qing. E-mail: caiqing@mail.buct.edu.cn
  • Supported by:

    国家自然科学基金(批准号: 50873012)资助.

Abstract:

Using N,N-dimethyl-ethylenediamine as cationic substitute and 2-hydroxyethyl methacrylate or allylamine as co-substitute, a kind of pH-sensitive polyorganophosphazenes bearing unsaturated side group was prepared. Their compositions and structures were confirmed by 1H NMR and FTIR analysis. Polyphosphazene gels could be obtained by radical crosslinking the polymers. These gels exhibited different water absorption behavior significantly depending on chemical composition, environmental pH, ion strength and ionic charge. The results revealed the pH-sensitive polyorganophosphazene hydrogels could be good candidates for the study of glucose-mediated insulin release in combination with glucose oxidase.

Key words: Polyorganophosphazene; Hydrogel; pH-sensitive

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