Synthesis of Amphiphilic Block Copolymer PCL-b-PDMAEMA by the Combination of Enzymatic-promoting Polymerization with ATRP and Its Self-assembly Behavior

Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (12): 2521.

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Synthesis of Amphiphilic Block Copolymer PCL-b-PDMAEMA by the Combination of Enzymatic-promoting Polymerization with ATRP and Its Self-assembly Behavior

LIU Lin-Lin^1,2, WANG Shu-Wei¹, LI Ya-Peng^1*, SA Zong\|Peng¹, ZHU Ming¹, PAN Si¹, YANG Yan-Ming²

1. A. G. McDiarmid Institute, Jilin University, Changchun 130012, China;
2. The Second Hospital of Jilin University, Changchun 130041, China

Received:2010-07-27 Revised:2010-11-01 Online:2010-12-10 Published:2010-12-06
Contact: Li Ya-Peng E-mail:liyapeng@jlu.edu.cn
About author:李亚鹏, 男, 博士, 副教授, 主要从事医用高分子材料的研究.
Supported by:
国家自然科学基金(批准号: 20904014)和教育部博士点基金(批准号: 20090061110017)资助.

Abstract

Abstract: Abstract: Amphiphilic poly(caprolactone)-block-poly(dimethylaminoethyl methacrylate) (PCL-b-PDMAEMA) is synthesized utilizing a chemoenzymatic approach. The structure, molecular weight and its distribution of the resultant are characterized by H-1 Nuclear Magnetic Resonance (1H NMR), Fourier Transfer Infrared Spectra (FT-IR), Gel Permeation Chromatography (GPC). The properties of the solution of the resultant is studied, suggesting an increased tendency of forming micelle in aqueous media with a higher proportion of hydrophobic segments in the polymer, demonstrating a decreased Critical Micelle Concentration and higher thermodynamic stability. Previous studies indicate that PDMAEMA is responsive to temperature and pH, having various configurations in different temperature and pH: average hydraulic diameter increases with a decreased pH and/or decreased temperature.

Key words: Chemoenzymatic, Amphiphilic block copolymer, solution properties

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LIU Lin-Lin, WANG Shu-Wei, LI Ya-Peng, SA Zong-Peng, ZHU Ming, PAN Si, YANG Yan-Ming. Synthesis of Amphiphilic Block Copolymer PCL-b-PDMAEMA by the Combination of Enzymatic-promoting Polymerization with ATRP and Its Self-assembly Behavior[J]. Chem. J. Chinese Universities, 2010, 31(12): 2521.

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Synthesis of Amphiphilic Block Copolymer PCL-b-PDMAEMA by the Combination of Enzymatic-promoting Polymerization with ATRP and Its Self-assembly Behavior

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