Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (1): 84.

• Articles • Previous Articles     Next Articles

Isolation and Identification of a New Compound from the Roots of Picrorhiza Scrophulariiflora

YIN Li-Zi1, OUYANG Ping1, XU Xue1, ZHOU Li-Guang1,2, WANG Da-Cheng1, DENG Xu-Ming1*   

  1. 1. College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China;
    2. Five-star Animal Health Pharmaceutical Factory of Jilin Province, Changchun 130062, China
  • Received:2009-04-01 Online:2010-01-10 Published:2010-01-10
  • Contact: DENG Xu-Ming. E-mail: xumingdeng@jluhp.edu.cn
  • Supported by:

    国家科技支撑计划(批准号: 200B6AD31B05, 2008BAD4B04-4)资助.

Abstract:

Xizang Huhuanglian, the roots of Picrorhiza scrophulariiflora Pennell, is a traditional Chinese Medicine used to treat damp-heat dysentery, jaundice, indigestion, common fever, acute viral hepatitis, and steaming of bone. The scholars of domestic and foreign have studied on the pharmacological effects of the plant, and found that the plant will be one of the most effective preparation in protecting the liver. This plant is rich in terpenoids, iridoid glycosides, phenolic glycosides and phenylethanoid glycosides. These compounds of the plant were isolated via silica gel column, D101 macroporous column, Sephadex LH-20 column, ODS column chromatography and HPLC. The structures of these compounds were identified by spectroscopic methods(NMR, IR, UV and MS) and chemical methods. Four compounds from this plant were obtained. Their names are Scrophenoside E(1) [(6-(4-acetyl-2-methoxyphenoxy)-3,5-dihydroxy-4-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)tetrahydro-2H-pyran-2-yl)methyl-3-methoxy-4-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)benzoate], Coniferin(2), Arbutin(3) and Androsin(4). Scrophenoside E is a new compound. Coniferin, Arbutin and Androsin are three known compounds.

Key words: Picrorhiza scrophulariiflora Pennell; Phenylethanoid glycosides; Scrophenoside E

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