Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (1): 74.

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Synthesis, Antioxidation Activity of Bridged Vinyl-8-hydroxyquinolin Derivative and Its Induction Proliferation of Mesenchymal Stem Cells

ZHANG Pei-Quan1*, ZENG He-Ping2   

  1. 1. Laboratory Center of Biology and Chemistry, Guangzhou Medical College, Guangzhou 510182, China;
    2. Institute of Functional Molecules, Faculty of Chemistry, South China University of Technology, Guangzhou 510641, China
  • Received:2009-04-07 Online:2010-01-10 Published:2010-01-10
  • Contact: ZHANG Pei-Quan. E-mail: pqzhang@yahoo.com.cn
  • Supported by:

    国家自然科学基金(批准号: 20471020, 20671036)和广东省科技计划项目(批准号: 2006A10801002)资助.

Abstract:

2-Vinyl-8-hydroxyquinolin derivative(6) was synthesized and characterized by IR, UV-Vis, 1H NMR, MS and elemental analysis. Meanwhile, the title compound was biologically evaluated by the MTT assay on the proliferation of rat mar-row-derived mesenchymal stem cells(rMSCs) and by the DPPH· method on the antioxidation activity. The results show that the title compound can induce the proliferation of mesenchymal stem cell compared with the control group under a low concentration condition and inhibitive effect on a higher concentration condition. The results also show that compound 6 has strong antioxidation activity. With concentration increasing, antioxidation activity is first increased and then decreased. It was found that the increasing antioxidant property of this protein depended quantitatively on the increase of its the compound 6 content.

Key words: 8-Hydroxyquinolin derivative; Antioxidation activity; Proliferation of mesenchymal stem cell

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