Chem. J. Chinese Universities ›› 2010, Vol. 31 ›› Issue (1): 46.

• Articles • Previous Articles     Next Articles

Serum EFAs and NEFAs Metabolic Profiling Analysis Child-bearing Age Women and Its Application to NTDs Preventive Nutrition Intervention

HAN Li-Da1,2, LIANG Qiong-Lin2, WANG Yi-Ming2, LUO Guo-An1,2*   

  1. 1. School of Pharmaceutics, East-China University of Science & Technology, Shanghai 200237, China;
    2. Analysis Center, Tsinghua University, Beijing 100084, China
  • Received:2009-04-06 Online:2010-01-10 Published:2010-01-10
  • Contact: LUO Guo-An. E-mail: luoga@mail.tsinghua.edu.cn
  • Supported by:

    国家“九七三”计划项目(批准号: 2007CB511903)资助.

Abstract:

Nutrition intervention(NI) is the common means for Neural tube defects(NTDs) prevention. The serum EFAs and NEFAs metabolic profiling of Child-bearing age women was studied by GC/MS method. The subjects were random divided into two groups: NI group(n=48) and control group(n=48). The mean levels of EFAs and NEFAs were reported. PLS-DA using the SIMCA-P software package allowed the different group to be distinguished, which means NI has great effects on the metabolism of fatty acids. Based on the quantification results, six FAs(both EFAs and NEFAs) were recognized as potential biomarkers. And the relationship between NI and the FAs′ concentration variation was discussed to illustrate the potential impacts on the incidence of NTD.

Key words: Nutrition intervention; Neural tube defects(NTDs); Fatty acid; Nutrition metabonomics; Biomarker

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