Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (7): 1353.

• Articles • Previous Articles     Next Articles

Novel Trifunctional Salicylaldehyde Schiff Base Derivative with GPX, SOD and CAT Activities

LI Huan-Min1, GAO Nan2, LIU Lei2, SHEN Si-Le1, LUO Gui-Min2*   

  1. 1. College of Life Science, Jilin University, Changchun 130012, China;
    2. Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130021, China
  • Received:2008-11-06 Online:2009-07-10 Published:2009-07-10
  • Contact: LUO Gui-Min. E-mail: luogm@jlu.edu.cn
  • Supported by:

    国家自然科学基金(批准号: 20572035)资助.

Abstract:

Glutathione peroxidase(GPX) is one of the most crucial antioxidant enzymes in a variety of organisms; it catalyzes the reduction of H2O2 by reduced glutathione(GSH). We used sodium salicylaldehyde-5-sulfonate as the parent of the mimic, then the catalytic group of GPX, —SeH, was introduced to obtain a salicylaldehyde Schiff base compound, which was chelated with Mn and oxidized in air to obtain the final product. Its structure was proved by NMR, MS, IR and its antioxidant ability was tested. The product was demonstrated to have GPX, SOD and CAT activities at the same time, good solubility in water and strong ability to resist oxidative damage. Thus, the trifunctional enzyme mimic possesses a good potential in medicinal application.

Key words: Glutathione peroxidase; Salicylaldehyde Schiff base; Selenium; Superoxide dismutase; Catalase

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