Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (12): 2521.

• Articles • Previous Articles     Next Articles

Poly(α,L-glutamic acid) Microspheres for Oral Insulin Delivery

HAN Ya-Dong1,2, XIA Jia-Liang1,2, HE Pan1,2, TIAN Hua-Yu1, CHEN Xue-Si1*, JING Xia-Bin1   

  1. 1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
    2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China
  • Received:2009-02-24 Online:2009-12-10 Published:2009-12-10
  • Contact: CHEN Xue-Si. E-mail: xschen@ciac.jl.cn
  • Supported by:

    国家自然科学基金(批准号: 50733003)、A3国际合作重大基金(批准号: 20621140369)、科技部国际合作重点项目(批准号: 20071314)和吉林省科技发展计划国际合作项目(批准号: 20060701)资助.

Abstract:

Insulin-loaded poly(α,L-glutamic acid) microspheres for oral delivery were prepared by anhydrous emulsion system. The microspheres had diameters of 5—20 μm, and drug loading of 5%—9%. The microspheres had good pH sensitive release behavior. In gastric simulated fluid about 5% of insulin was released from microspheres after 2 h, while in intestinal simulated fluid over 90% of insulin released. The effect of polymer molecular weight, theoretical drug loading and polymer solution concentration to the microsphere release profile were investigated.

Key words: Poly(α,L-glutamic acid); Microsphere; Oral insulin delivery; Anhydrous emulsion; pH-sensitive drug release

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