Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (12): 2419.

• Articles • Previous Articles     Next Articles

One-pot Synthesis and Biodistribution of 6-[18F]Fluoro-6-deoxy-D-glucose(6-18FDG) as Potential Glucose Transport Imaging Agent

ZHANG Zheng-Wei1,2, QIAN Jun1, XUE Fang-Ping2, LIU Ping2, LI Yan-Ru1, GUAN Yi-Hui2*, ZHU Jian-Hua1*   

  1. 1. Department of Radiopharmacy, School of Pharmacy, Fudan University, Shanghai 200232, China;
    2. PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
  • Received:2009-02-23 Online:2009-12-10 Published:2009-12-10
  • Contact: ZHU Jian-Hua. E-mail: jhzhu@shmu.edu.cn; GUAN Yi-Hui. E-mail: guanyihui@hotmail.com
  • Supported by:

    国家“九七三”计划项目(批准号: 2007CB935800)资助.

Abstract:

For the development glucose transport imaging, a radioactive glucose analogue was synthesized and evaluated. A glucose analogue, 6-[18F]fluoro-6-deoxy-D-glucose(6-18FDG), was prepared in two steps with one-pot synthesis from [18F]fluoride and tosyl-precursor. Starting with D-glucose, the D-glucose was reacted with acetone and benzaldehyde to protect hydoxy, then reacted with p-toluenesulfonyl choride(TsCl) to get the tosyl-precursor. All the intermediates were identified with NMR and MS. The total radiosysthesis spent 35 min and with 70%±5%(EOB, decay corrected, n=5), with the radiochemical purity>95%. Biodistribution of 6-18FDG was performed in mice: 18F activities in brain, liver, and heart reach the peak in 1.0 min after the injection, so reached a constant level. These results support that 6-18FDG is promising as valid tracer of glucose transport.

Key words: Positron emission tomography; Glucose transport; 6-[18F] Fluoro-6-deoxy-D-glucose; One-pot synthesis

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