Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (12): 2415.

• Articles • Previous Articles     Next Articles

Synthesis of Hydrochloride of Bis(dimethoxypropylphosphinoethyl)-ethoxyethylamine

CHU Jin-Feng1*, WANG Xue-Bin2   

  1. 1. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China;
    2. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
  • Received:2009-03-10 Online:2009-12-10 Published:2009-12-10
  • Contact: CHU Jin-Feng. E-mail: jfchu@163.com
  • Supported by:

    北京化工大学青年教师自然科学研究基金(批准号: QN0624)资助.

Abstract:

[99mTcN(PNP5)(DTC)]+[PNP5: bis(dimethoxypropylphosphinoethyl)-ethoxyethylamine, DTC: dithiocarbamate] heterocomplexes can be viewed as resulting from the selective coupling of the metal fragment [99mTcN(PNP5)]2+ with the bidentate dithiocarbamate π-donor ligand, and these complexes have attractive potential for myocardial perfusion imaging agents. In this article, PNP5 hydrochloride was synthesized from 2-ethoxyethylamine and 3-chloro-1-propanol through seven steps successively, in which the last two steps were the key. The structure of PNP5 hydrochloride was affirmed by IR, 1H NMR, 13C NMR, 31P NMR, MS and Elemental analysis.

Key words: Bis(dimethoxypropylphosphinoethyl)-ethoxyethylamine(PNP5) hydrochloride; Tertiary phosphine complex; 2-Ethoxyethylamine; 3-Chloro-1-propanol

TrendMD: