Chem. J. Chinese Universities ›› 2009, Vol. 30 ›› Issue (11): 2319.

• Articles • Previous Articles     Next Articles

Preparation and Characterization of the CS/BSA Composite Micropatterns on Silicon Surfaces

XIE Jia1, LU Xiong2,3*, ZHANG Hong-Ping2, ZHOU Xian-Li1, QU Shu-Xin2, FENG Bo2, WENG Jie2   

  1. 1. School of Life Science and Engineering,
    2. Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China;
    3. Department of Mechanical Engineering, Hong Kong University of Science and Technology, HongKong, China
  • Received:2009-01-16 Online:2009-11-10 Published:2009-11-10
  • Contact: LU Xiong. E-mail: luxiong_2004@163.com
  • Supported by:

    国家自然科学基金(批准号: 30700172)、自然科学基金中港联合基金(批准号: N_HKUST601/08, 30831160509)、高等学校博士学科点专项科研(新教师)基金(批准号: 20070613019)和国家科技支撑计划(批准号: 2006BAI16B01)资助.

Abstract:

Chitosan/Bovine serum albumin(CS/BSA) composite micropatterns were successfully fabricated on silicon surfaces by micro-transfer molding method. The micropatterned CS/BSA composite films were stu-died by optical microscopy and fluorescent microscopy. A quantitative test was carried out to characterize the antibacterial properties of the CS/BSA composite films. The results show that the micropatterned CS/BSA composite films are effectively against E. coli and Staphylococcus albus. MC3T3-E cell culture test indicated that micropatterned CS/BSA composite films could strongly direct the orientation of cells. Moreover, the micropatterned CS/BSA composite films could promote the cell adhesion, spreading, proliferation and differen-tiation. Thus, the micropatterned CS/BSA composite film fabricated by micro-transfer molding method has good antibacterial properties and cell compatibility.

Key words: Micropattern; CS/BSA composite micropattern; Micro-transfer molding method; Antibacterial property; Cell compatibility

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