Preparation of Controlled-release Microspheres Loading Protein Through Solid-in-oil-in-water Emulsion Method

Chem. J. Chinese Universities

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Preparation of Controlled-release Microspheres Loading Protein Through Solid-in-oil-in-water Emulsion Method

DU Qing^1,2, HU Jun-Li^1,2, HAN Ya-Dong^1,2, CHEN Xue-Si¹*, JING Xia-Bin¹

1. State Key Laboratory of Polymer Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China

Received:2007-11-20 Revised:1900-01-01 Online:2008-06-10 Published:2008-06-10
Contact: CHEN Xue-Si

Abstract

Abstract: A novel solid-in-oil-in-water(S/O/W) emulsion method for drug controlled-release system was investigated in this paper. Bovine serum albumin(BSA) was used as the model drug. At first, the nanoparticles containing proteins were obtained by adsorbing BSA from the solution onto the surface of nano-scale SiO₂. Then PLGA microspheres loading the solid nanoparticles were fabricated with the solid-in-oil-in-water emulsion method. Compared with the traditional water-in-oil-in-water double emulsion method, this new method has marked advantages, such as improving the percentage of drug in microspheres and the drug entrapment efficiency. More importantly, the activities of protein could be retained better.

Key words: Nano-scale SiO₂, Solid-in-oil-in-water(S/O/W) emulsion method, Protein drug, Drug controlled release

CLC Number:

O633.14

TrendMD:

DU Qing^1,2, HU Jun-Li^1,2, HAN Ya-Dong^1,2, CHEN Xue-Si¹*, JING Xia-Bin¹. Preparation of Controlled-release Microspheres Loading Protein Through Solid-in-oil-in-water Emulsion Method[J]. Chem. J. Chinese Universities, doi: .

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Preparation of Controlled-release Microspheres Loading Protein Through Solid-in-oil-in-water Emulsion Method

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