CJCU

Chem. J. Chinese Universities

• 研究论文 • Previous Articles     Next Articles

Synthesis, Characterization and DNA-Binding Studies of Ruthenium Complex [Ru(bpy)2(PNT)]2+

SUN Bin, LIANG Si-Min, WANG Yu-Chuan, CHAO Hui*, JI Liang-Nian*   

  1. School of Chemistry and Chemical Engineering, Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, Sun Yat-Sen University, Guangzhou 510275, China
  • Received:2008-10-06 Revised:1900-01-01 Online:2008-12-10 Published:2008-12-10
  • Contact: CHAO Hui, JI Liang-Nian

PDF (PC)

Abstract: A novel ruthenium complex [Ru(bpy)2(PNT)]2+ (bpy=2,2’-bipyridine, PNT=2-[4’-(1H-tetrazol-5-yl)phenyl]-1H-imidazo[4,5-f][1,10]phenanthroline) was synthesized and characterized by elemental analysis, electrospray mass spectra and 1H NMR. The binding of the complexes with calf thymus DNA was investigated by absorption spectroscopy, luminescence titrations, viscosity measurements and DNA thermal denaturation experiments. The experimental results suggest that [Ru(bpy)2(PNT)]2+ binds with DNA by partial intercalation.

Key words: Ruthenium(Ⅱ) complex, CT-DNA, Partial intercalation

CLC Number: 

TrendMD: