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Isolation and Structure Characterization of Malonyl-notoginsenoside-R4 from the Root of Panax ginseng

SUN Guang-Zhi1, LI Xiang-Gao2, LIU Zhi1, WANG Ji-Yan3, ZHENG Yi-Nan2, YANG Xiu-Wei4*   

    1. Institute of Biotechnological Prevention and Control,
    2. College of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, China;
    3. College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130118, China;
    4. State Key Laboratory of Natural & Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
  • Received:2006-09-01 Revised:1900-01-01 Online:2007-07-10 Published:2007-07-10
  • Contact: YANG Xiu-Wei

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Abstract:

A new malonylated dammarane-type triterpene oligoglycoside, named malonyl-notoginsenoside-R4(1), was isolated from the fresh root of Panax ginseng C. A. Mey. The structure of malonyl-notoginsenoside-R4 was determined as 3-O-[6-O-malonyl-β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-[β-D-xylopyranosyl(1→6)-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl]-20(S) protopanaxadiol on the basis of physicochemical properties and spectral analysis.

Key words: Panax ginseng, Fresh ginseng radix, Triterpenoid, Malonyl-notoginsenoside-R4

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