Abstract: In water solution with pH=5.0—9.0, the CdS nanoparticles[(CdS)_n] can react with a kind of anthracycline anticancer drugs such as MXT, DNR and EPI to form the larger aggregates by virtue of electrostatic attraction and hydrophobic force. The aggregates arouse Resonance Rayleigh scttaring(RRS) instancing greatly, and the new RRS spectra appeared. The maximum RRS peaks are at 292 nm for MXT system, 285 nm for DNR system and 315 nm for EPI system, respectively. At the same time, the Second-order Scattering(SOS) and Frequency-double Scattering(FDS) are also enhanced obviously. The maximum SOS peaks are at 540 nm for MXT system, 560 nm for EPI system and DNR system, but their maximum FDS peak are at 320 nm for EPI system, 330 nm for DNR system and 330 nm for MXT system, separately. The enhancements of three scattering(ΔI) are directly proportional to the concentration of anthracycline drugs in a certain ranges. The reactions have high sensitivities, the detection limits for different drugs are 3.6—9.1 ng/mL. Among them, (CdS)_n-MXT system is the most sensitive, its limits for MXT are 4.1 ng/mL for RRS method, 3.8 ng/mL for SOS method and 3.6 ng/mL for FDS method, respectively. So a new method for the determination of the anthracycline anticancer drugs with CdS nanoparticles as probe is developed, the method is highly sensitive, and it is very simple and fast.

Key words: CdS nanoparticles, Resonance Rayleigh scattering, Aanthracycline anticancer drugs