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Chem. J. Chinese Universities

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Separation and Identification of New Furosteroidal Saponin from Ophiopogon japonicus(Thunb.) Ker-Gawl

XU Tun-Hai1, CHEN Ping2, XU Ya-Juan2, HAO Ling-Zhu2, XIE Sheng-Xu2, XU Dong-Ming2   

    1. College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China;
    2. Academy of Traditional Chinese Medicine and Material Medica of Jilin Province, Changchun 130021, China
  • Received:2006-03-06 Revised:1900-01-01 Online:2007-02-10 Published:2007-02-10
  • Contact: XU Ya-Juan

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Abstract: Traditional Chinese Medicine “maidong”[Ophiopogon japonicus(Thunb.) Ker-Gawl] is the important medicine used to treat cardiovascular diseases. A new furosteroidal saponin, together with three known steroidal saponins, was isolated from the tuber of Ophiopogon japonicus(Thunb.) Ker-Gawl. The structure of the new furosteroidal saponin, named Ophiopogoside A, was elucidated as 26-O-β-D-glucopyranosyl-(25S)-1β,3β,22α,26-tetrahydroxyfurot-5-ene 3-O-[-α-L-arabinopyranosyl(1→3)]-α-L-rhamnopyranosyl(1→2)-β-D-fucopyranoside mainly by using 1D, 2D NMR techniques, ESI-MS analysis as well as chemical methods.

Key words: Ophiopogon japonicus, Steroidal saponin, Ophiopogoside A

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