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Chem. J. Chinese Universities ›› 2006, Vol. 27 ›› Issue (5): 939.doi:

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NMR Study on Inclusion-complex of Cyclodextrin with α-Naphthylacetic Acid

PENG Min, KONG Xu-Xin, YU Yi-Hua, CHEN Qun*   

  1. Department of Physics, the Key Laboratory for Optics and Magnetic Resonance Spectroscopy of Education Ministry, East China Normal University, Shanghai 200062, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-05-10 Published:2006-05-10
  • Contact: CHEN Qun

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Abstract:

The interactions of α-naphthylacetic acid(α-NAA) with α-cyclodextrin(α-CD) and β-cyclodextrin(β-CD) were studied by NMR diffusion measurements, 1H-1H ROESY and solid-state high-resolution 13C NMR spectroscopy. Both α-CD and β-CD are found to be able to form inclusion-complex with α-NAA. The complex formed by β-CD and α-NAA are more stable than that formed by α-CD and α-NAA, due to the effect of cavity size. The association constant of β-CD/α-NAA complex was calculated from the self-diffusion coefficients of α-NAA. The application of β-CD/α-NAA system in drug release was discussed.

Key words: NMR; ROESY; 13C CP/MAS; Self-diffusion coefficient; Inclusion complex

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