Synthesis and Characterization of Amphiphilic Triblock Copolymers PAA-PHB-PAA

Chem. J. Chinese Universities ›› 2006, Vol. 27 ›› Issue (4): 784.

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Synthesis and Characterization of Amphiphilic Triblock Copolymers PAA-PHB-PAA

ZHANG Xue-Qin¹, ZHENG Yun¹, YANG Hu¹, LIU Quan-Wei¹,XIE Hong-Feng¹, WANG Zhi-Liu¹, CHENG Rong-Shi^1,2*

1. Key Laboratory for Mesoscopic Chemistry of Ministry of Education, Department of Polymer Science & Engineering, College of Chemistry & Chemcal Engineering, Nanjing University, Nanjing 210093, China;
2. Polymer Institute, College of Material Science and Engineering, South China University of Technology, Guangzhou 510640, China

Received:2005-06-10 Online:2006-04-10 Published:2006-04-10
Contact: CHENG Rong-Shi, E-mail: rscheng@nju.edu.cn

Abstract

Abstract:

A new biodegradable PtBA-PHB-PtBA triblock copolymer was successfully synthesized by ATRP method with Br-PHB-Br as macroinitiator, tert-butyl acrylate as monomer and CuBr/PMDETA as the catalyst system. Cleavage of the tert-butyl ether groups of the PtBA-PHB-PtBA triblock copolymer was then performed via hydrolysis with trifluoroacetic acid as the catalyst in dichloromethane to afford the amphiphilic PAA-PHB-PAA triblock copolymer. The hydrolysis is successful but trace tert-butyl ether groups still remain in the backbone. The molecular weight characteristics and chain structures were conformed by GPC and NMR, respectively. Because of hydrophilic and biocompatibility, the amphiphilic triblock copolymers have potential applications in the field of drug release.

Key words: Atom transfer radical polymerization; Amphiphilic triblock copolymer; Synthesis; Characterization

CLC Number:

O631

TrendMD:

ZHANG Xue-Qin, ZHENG Yun, YANG Hu, LIU Quan-Wei, XIE Hong-Feng, WANG Zhi-Li. Synthesis and Characterization of Amphiphilic Triblock Copolymers PAA-PHB-PAA[J]. Chem. J. Chinese Universities, 2006, 27(4): 784.

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Synthesis and Characterization of Amphiphilic Triblock Copolymers PAA-PHB-PAA

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