Micellization of Poly(L-alanine)/Poly(ethylene glycol) Block Copolymer

Chem. J. Chinese Universities ›› 2006, Vol. 27 ›› Issue (4): 767.

• Articles • Previous Articles Next Articles

Micellization of Poly(L-alanine)/Poly(ethylene glycol) Block Copolymer

ZHANG Guo-Lin ^1,2, MA Jian-Biao ²*, WANG Yi-Nong²

1. School of Chemical Science and Engineering, Liaoning University, Shenyang 110036, China;
2. State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China

Received:2005-03-24 Online:2006-04-10 Published:2006-04-10
Contact: MA Jian-Biao, E-mail: jbma@nankai.edu.cn

Abstract

Abstract:

Block copolymers of poly(L-alanine)/poly(ethylene glycol)(PAME) were synthesized by ring opening polymerization and their structures were characterized. The secondary structure was investigated by circular dichroism(CD). The micellization and critical micelle concentrations(CMC) of PAME in water were monitored by fluorescent probe technique. The diameter and distribution of micelles were characterized by DLS and its shape was observed by TEM. The results show that the poly(amino acid) segment of block copolymer chains existed as α-helical conformation in aqueous solution. The block copolymers of PAME-1 and PAME-2 could form spherical micelles at room temperature, whose diameter was about several hundred nanometer. The CMC of PAME-1 micelle was 1.99×10^-5 mol/L, which depends on the PLA content of the copolymers.

Key words: Poly(amino acid); Block copolymer; Ring-opening polymerization; α-Helical structure; Micellization; Critical micelle concentration

CLC Number:

O632

TrendMD:

ZHANG Guo-Lin, MA Jian-Biao, WANG Yi-Nong. Micellization of Poly(L-alanine)/Poly(ethylene glycol) Block Copolymer[J]. Chem. J. Chinese Universities, 2006, 27(4): 767.

[1]	WANG Heng-Guo, LIU Da-Hai, ZHANG Chao-Qun, LI Yao-Xian, YANG Qing-Biao, DU Jian-Shi. Preparation and Characterization of Fluorescent Nanofiber Based on Fluorescein [J]. Chem. J. Chinese Universities, 2012, 33(05): 1074.
[2]	WANG Yong-Peng, YUE Xi-Gui, PANG Jin-Hui, LI Xue-Feng, LI Na, ZHANG Hai-Bo, JIANG Zhen-Hua. Synthesis and Properties of Poly(aryl ether sulfones) Functionalized with Pendant Perfluoroalkyl Sulfonic Acid for Proton Exchange Membrane [J]. Chem. J. Chinese Universities, 2012, 33(05): 1100.
[3]	WEI Yu, JI Ying, JI Jian. REDV/Peptide Conjugated Rapamycin-loaded Polymer Matrix for Endothelial Cells Selectivity [J]. Chem. J. Chinese Universities, 2012, 33(01): 193.
[4]	LI Zhi-Jun, XIE Xu-Ming, GUO Bao-Hua . Reactive Blend Systems of PA6/HIPS/PP-g-(GMA-co-St) [J]. Chem. J. Chinese Universities, 2004, 25(10): 1941.
[5]	RONG Jian-Hua, JI Li-Jun, NIU Zhong-Wei, LI Dan, MA Jin, YANG Zhen-Zhong . Template-synthesis and Characterization of Responsive Ordered Macroporous Hydrogels [J]. Chem. J. Chinese Universities, 2004, 25(9): 1771.
[6]	LIAN Hui-Qin, WU Xue. Synthesis and Photochromism Property of Three Naphthacenequinone Phenolic Resins [J]. Chem. J. Chinese Universities, 2004, 25(9): 1740.
[7]	LI Li-Dong, WANG Qi, FAN Zhi-Qiang . Synthesis of Polyethylene with Bimodal Molecular Weight Distribution by Iron-based Late Transition Metal Catalyst/Various Aluminoxanes System [J]. Chem. J. Chinese Universities, 2004, 25(9): 1777.
[8]	ZHANG Bin, ZHANG Zhao-Bin, WAN Xiao-Long, HU Chun-Pu , YING Sheng-Kang. Synthesis and Characterization of Gradient Copolymer Composed of Styrene and Methyl Methacrylate in Water Dispersion System [J]. Chem. J. Chinese Universities, 2004, 25(6): 1170.
[9]	ZHAO Yan, WANG Qi, FENG Lin-Xian . UV Studies on Aluminoxane EBAO and Its Influence on Ethylene Polymerization [J]. Chem. J. Chinese Universities, 2001, 22(11): 1948.
[10]	MA Hai-Yan, ZHANG Yue, CHEN Bin, HUANG Ji-Ling, QIAN Yan-Long  . Studies on Syndiospecific Polymerization of Styrene Catalyzed by CpTiCl₂(OR)/MAO System [J]. Chem. J. Chinese Universities, 2001, 22(7): 1259.
[11]	HU Zhi-Guo, ZHANG Yi-Feng, SHEN Zhi-Quan . Alternating Copolymerization of Isoprene with Maleic Anhydride by Rare Earth Coordination Catalyst [J]. Chem. J. Chinese Universities, 2001, 22(6): 1049.
[12]	LIN Xian-Fu, HE Lin, XU Li-Heng, LÜ De-Shui, CHEN Zhi-Chun . Studies on the Lipase Monolayer Film Self-assembly on the Nagatively Charged Poly(ethylene terephthalate) Substrate [J]. Chem. J. Chinese Universities, 2001, 22(4): 683.
[13]	GUAN Jian-Jun, GAO Chang-You, SHEN Jia-Cong . Preparation and Characterization of Cell Compatible Polyurethane [J]. Chem. J. Chinese Universities, 2001, 22(2): 317.
[14]	NI Xu-Feng, LI Wei-Shi, ZHANG Yi-Feng, SHEN Zhi-Quan, ZHANG Tian-Xu. Polymerization of1,3-Butadiene with Novel Calixarene Rare Earth Complex Based Homogeneous Catalysts [J]. Chem. J. Chinese Universities, 2000, 21(12): 1936.
[15]	ZHANG Yong-Ming, LUO Ning, YING Sheng-Kang . Studies on Synthesis of Graft Copolymers with p-Chloromethyl-styrene Copolymers as Macroinitiators [J]. Chem. J. Chinese Universities, 1999, 20(3): 492.

Micellization of Poly(L-alanine)/Poly(ethylene glycol) Block Copolymer

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments