Abstract:

AbstractThe effects of novel green solvents,ionic liquids(ILs),on the structures of phospholipid liposomes as model bio-membranes were studied.  The ILs-liposomes suspensions were characterized by turbidity,DSC and ³¹P NMR, and the results obtained demonstrate that  the interaction between water-miscible 1-n-alkyl-3-methylimidazolium ILs and  liposomes eventually led to the rupture of the liposome structures and the solubilization of the phospholipid components.  In the process,[C_nmim] cations played a crucial role in the solubilization of phospholipid liposomes,and the anion types and alkyl chain lengths also had influence on solubilizing properties of these ILs.  A possible mechanism involved in the ILs-induced solubilization of phospholipid liposomes was proposed.

Key words: Phospholipid; Liposome; Ionic liquid; Solubilization; Turbidity