Abstract:

To prepare 20(S)-protopanaxidiolone natural sapogenin in Panax Ginseng C.A.,the method of alkali catalyzing degradation was used.  20(S)-Protopanaxidiol was separated and it′s structure was characterized.  The total saponins from leaves and stems of Panax qinquefolium L.  and strong alkali were solved in  an organic solvent  with a high boiling point,then the degradation was performed at  high temperature and common pressure.  The optimal condition of degradation was confirmed through orthogonal experiment.  20(S)-Protopanaxidiol was separated and purified by extraction,column chromatography and recrystal from the degradation products.  The obtained yield of 20(S)-protopanaxidiol was 5.01%  accounting for the total saponins and the purity  of 20(S)-protopanaxidiol was 98.56%.  The structure of the compound was elucidated by characteristics and spectral analysis as 20(S)-protopanaxidiol.  The characteristics of the method were proved to be high yield,high purity and low costing in  20(S)-protopanaxidiol preparation. 

Key words: 20(S)-Protopanaxidiol; Preparation; Alkali; Catalysis; Degradation; Antitumor