CJCU

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (8): 1446.

• Articles • Previous Articles     Next Articles

Effect of Bupleurun Chinese DC(BCDC) on the MDR Reversal of Hepatocellular Carcinoma and Related Mechanism

GAI Xiao-Dong1, ZENG Chang-Qian1, HONG Min2   

  1. 1. Laboratory of Life Science and Biological Technology, Beihua University, Jilin 132013, China;
    2. Medicine Protein and Proteomics laboratory, Jilin University, Changchun 130023, China
  • Received:2004-10-29 Online:2005-08-10 Published:2005-08-10

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Abstract: The reversal effect and mechanisms of BCDC were evaluated by using Bel-7402 cell line with innate resistance in this study. The identification of new and less toxic reversal agent, BCDC, would open a new perspectives in cancer treatment. The results show that BCDC has an effect on MDR reversal of Bel-7402 cell line and a synergetic effect with VCR. The reversal mechanisms were due to suppress MDR1 transcription and P-gp expression, as a result, to leave TopoⅡα mRNA level, to increase intracellular VCR concentration of Bol-7402 cell, to enhance cell G2M phase arrest induced by VCR.

Key words: Hepatocellular carcinoma, Multidrug resistance(MDR), MDR reversal, Vincristine(VCR), Bupleurun Chinese DC

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