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Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (2): 235.

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Identification and Quantification Analysis of Active Ingredient and Main Impurities in Monosulfuron

FAN Zhi-Jin1, QIAN Chuan-Fan2, AI Ying-Wei3, CHEN Jun-Peng1, LI Zheng-Ming1   

  1. 1. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China;
    2. Key Laboratory of Pesticide Chemistry & Application Technology of Ministry of Agriculture, College of Science, China Agricultural University, Beijing 100094, China;
    3. College of Life Science, Sichuan University, Chengdu 610065, China
  • Received:2004-01-20 Online:2005-02-10 Published:2005-02-10

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Abstract: Monosulfuron was identified by m.p., IR, NMR, MS, UV and HPLC/MS analysis in this study, the results indicate that, the active ingredient of monosulfuron was N-[2'-(4'-methyl) pyrimidyl]-2-nitrobenzensulfonylurea, it's main impurities were 2-amino-4-methylpryrimidine, 2-nitrobenzensulfonamide and ethyl 2-nitrobenzensulfonyl carbamate. The method of reverse HPLC analysis for active ingredient and main impurities in monosulfuron were established by using 250 mm× 4.6 mm stainless column of ODS 5 μm with V(CH3OH)∶V(H2O)= 60∶40 containing H3PO4 ( pH 3.0) as a mobile phase, 0.8 mL/min of flow rate, 225 nm as UV determination wave length. All components of monosulfuron which consisted of more than 0.1% were quantitated.

Key words: Monosulfuron, Sulfonylurea herbicide, HPLC/MS

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