CJCU

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (11): 2160.

• Articles • Previous Articles     Next Articles

Synthesis and Characterization of Injectable Supramolecular Structured Hydrogels Prepared by Free Radical Polymerization of PLA-b-PEG-b-PLA Macromers and α-Cyclodextrins

ZHU Kai-Qiang, WEI Hong-Liang, HE Ji-Yu, QIAN Li-Jun, HOU Dan-Dan, ZHANG Ai-Ying, FENG Zeng-Guo   

  1. School of Materials Science and Engineering,Beijing Institute of Technology, Beijing 100081,China
  • Received:2004-11-11 Online:2005-11-10 Published:2005-11-10

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Abstract: Poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) triblock copolymer(PLA-PEG-PLA) was synthesized by the ring-opening polymerization of L-lactide with poly(ethylene glycol)(PEG6000) as the initiator and Sn(Oct)-2 as the catalyst in toluene.This copolymer was further reacted with methacrylic anhydride to give a soluble macromer terminated with methacryloyl groups.Two kinds of supramolecular structured hydrogels were obtained through mixing the macromer with α-cyclodextrins and then initiating by using ammonium persulphate with ascorbic acid or ferrous sulfate.The macromer and hydrogels were characterized by 1H NMR,FTIR,TGA and XRD etc..Based on rheological test,the two kinds of the resultant hydrogels are injectable with appropriate pot-life.

Key words: Macromers, Redox initiator, α-Cyclodextrins, Supramolecular structured hydrogel, Injectable property

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