Abstract: Based on the features of active structures of (E)-β-farnesene(EBF) analogues summarized by Nishino and Bowers, 13 compounds(Ⅰ₁-Ⅰ₁₃) with a novel framework were designed by the method of linking active sub-structures which had the active framework of EBF analogues and the active structure of Neonicotinoid insecticide analogues. Thus, the target compounds were prepared in 24%-59% yield through 2-3 step reactions from the starting material geraniol. Their structures were confirmed by IR, ¹H NMR, and MS. The results of bioassay demonstrated that most of the compounds show an obvious activity against adult Lipaphis erysimi at the test concentration. Especially at a lower concentration, some of them had a better activity than imidacloprid. For example, Ⅰ₁₀ and Ⅰ₁₃ exhibited respectively 93.1% and 87.1%, but imidacloprid showed 66.7% inhibiting rate at 25 mg/L.

Key words: EBF, EBF analogues, Synthesis, Biological activity