Synthesis, Relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) Complexes with Dihydropyridine Derivatives of Diethylenetriaminepentaacetic Acid

Abstract

Abstract: Four novel ligands of DTPA-dihydropyridine derivatives which were designed for magnetic resonance imaging contrast agents were synthesized by the reaction between DTPA-dianhydride and 4-aniline-1,4-dihydropyridines. Their complexes of gadolinium, manganese and iron were prepared. Spin-lattice relaxivities(t₁) of the complexes was investigated. The results showed that all the complexes have relaxation effects on the protons in surrounding water molecules. The Gd(Ⅲ) complexes have higher relaxivities than those of Fe(Ⅲ) and Mn(Ⅱ) complexes. The NMR t₁ relaxivities(R₁) of Gd(Ⅲ)DTPA-dihydropyridines complexes are 5.50, 5.58, 5.20 and 5.49 L·mmol^-1·s^-1, which are higher than that of their parent complex, GdDTPA^2-. That indicating that the Gd(Ⅲ) complex possesses the precondition to be the contrast agents for magnetic resonance imaging.

Key words: Diethylenetriaminepentaacetic acid, Dihydropyridine, Magnetic resonance imaging contrast agent, Relaxivity

CLC Number:

O623.626

TrendMD:

ZHENG Shu-Zhan, JIAN Ya-Jun, BAI Yin-Juan, XIE Zhan-Feng, CHANG Jian-Hua. Synthesis, Relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) Complexes with Dihydropyridine Derivatives of Diethylenetriaminepentaacetic Acid[J]. Chem. J. Chinese Universities, 2004, 25(9): 1652.

References

[1] 　L auffer R.B..Chem.R ev.[J],1987,87:901—927 [2] 　A nd réE.M erbach,Eva Tóth.T he chem istry of Con trast A gen ts in M ed icalM agnetic R esonance Im ag ing[M],N ew Yo rk:John W iley&Son s,L td.,2001:45—121 [3] 　HU Chao-Fen(胡朝芬),LU O L ai-H ua(罗来华).Jou rnal of P ractical R ad io logy(实用放射学杂志)[J],2002,18(15):431—434 [4] 　L IN R i-Zeng(林日增),ZHAN G Xue-L in(张雪林).N ew M ed.(新医学)[J],1999,30(3):173—174 [5] 　H E Guo-X iang(何国祥),W AN G Y i-X iang(王毅翔).Pharm aco logy and C lin ical A pp lication of Con trast A gen ts(造影剂药理学及临床应用)[M],Shanghai:Shanghai Science and Technology Press,2002:29—44 [6] 　W E I J un-Fa(魏俊发),ZHU O R en-X i(卓仁禧).Chem.J.Ch inese U n iversities(高等学校化学学报)[J],1998,19(8):1242—1246 [7] 　LU O Y i(罗毅),ZHU O R en-X i(卓仁禧),FAN Chang-L ie(范昌烈).Chem.J.Ch inese U n iversities(高等学校化学学报)[J],1995,16(9):1476—1479 [8] 　FU Yan-J un(傅雁军),ZHU O R en-X i(卓仁禧).Chem.J.Ch inese U n iversities(高等学校化学学报)[J],1997,18(7):1072—1079 [9] 　L I X in-Yu(李欣宇),ZHAN G Shan-Rong(张善荣),J IN G Feng-Y ing(景凤英)et al..Chem.J.Ch inese U n iversities(高等学校化学学报)[J],1998,19(12):2026—2028 [10] 　XU Yue-Hong(徐月红),XU L ian-Y ing(徐莲英).Ch in.Pharm.J.(中国药学杂志)[J],2002,37(8):569—573 [11] 　Chen P.,Bodo r N.,M eiw u W.et al..J.M ed.Chem.[J],1998,41:3773—3781 [12] 　R eiw ei P.,R umm eny E.J.,D u ld rup H.E.et al..R ad io logy[J],1995,195(2):489—496 [13] 　LU J un(路军),BA I Y in-J uan(白银娟),YAN G B ing-Q in(杨秉勤)et al..Ch inese J.O rg.Chem.(有机化学)[J],2000,20(4):514—517 [14] 　YAN G Guan-Yu(杨贯羽),SON G Yan-L in(宋延林),J I Yao-W u(嵇耀武)et al..J.Zhengzhou U n iv.,N atu ral Science Ed ition,(郑州大学学报,自然科学版)[J],1996,28(2):86—89 [15] 　Bo ssert F.,V ater W..S.A frican 6 801 482[P],1968 [16] 　W E I J un-Fa(魏俊发),ZHU O R en-X i(卓仁禧).Ch in.Sci.Bu lliten(科学通报)[J],1997,42(14):1519—1524