Studies on the Relaxivities of Novel MRI Contrast Agents──Two Water-soluble Derivatives of Gd@C82

Abstract

Abstract: The water proton relaxivities of two water-soluble derivatives of Gd@C₈₂ [Gd@C₈₂ (OH)₂₂ and Gd@C₈₂ (OH)₆(NHCH₂CH₂SO₃H)₈] were determined to be r₁=42.3 mmol^-1 ·L·s^-1 , r₂=90.9 mmol^-1 ·L·s^-1 ; r₁=4.5 mmol^-1 ·L·s^-1 , r₂=8.9 mmol^-1 ·L·s^-1 , respectively at (37±1) ℃ by a 1.5 T spin-echo method. The relaxation mechanism was discussed and the reason why the relaxivities of Gd@C₈₂ (OH)₂₂ is an order of magnitude higher than that of Gd@C₈₂ (OH)₆ (NHCH₂CH₂SO₃H)₈ were explained.

Key words: Endohedral metallofullerenes, Water-soluble derivatives, MRI contrast agent, Relaxivity

CLC Number:

O641

TrendMD:

LU Xing, XU Jian-Xun, SHI Zu-Jin, SUN Bao-Yun, GU Zhen-Nan, LIU Hong-Dong, HAN Hong-Bin . Studies on the Relaxivities of Novel MRI Contrast Agents──Two Water-soluble Derivatives of Gd@C₈₂[J]. Chem. J. Chinese Universities, 2004, 25(4): 697.

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Studies on the Relaxivities of Novel MRI Contrast Agents──Two Water-soluble Derivatives of Gd@C₈₂

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