Total Syntheses of (±)-3,5-Dihydroxy-7,4′-dimethoxy-dihydroflavonol and (±)-3,5,7-Trihydroxy-4′-methoxy-dihydroflavonol

Chem. J. Chinese Universities ›› 2004, Vol. 25 ›› Issue (2): 292.

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Total Syntheses of (±)-3,5-Dihydroxy-7,4′-dimethoxy-dihydroflavonol and (±)-3,5,7-Trihydroxy-4′-methoxy-dihydroflavonol

ZHANG Ying-Peng, LI Ying, XUE JI-Jun, NIU Ying-Hui, WU Jiang

State Key Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, China

Received:2002-12-31 Online:2004-02-24 Published:2004-02-24

Abstract

Abstract: Dihydroxy-7,4′-dimethoxy-dihydroflavonol and (±)-3,5,7-trihydroxy-4′-methoxy-dihydroflavonol were found in many medicinal plants, here we describe a concise synthesis route by selective protection, aldol-condensation, 30% H₂O₂ epoxidation, cyclization and deprotection from²,4,6-trihydroxyacetophone and anisaldehyde.

Key words: Dihydroflavonol, 3,5-Dihydroxy-7,4′-dimethoxy-dihydroflavonol, 3,5,7-Trihydroxy-4′-methoxy-dihydroflavonol, Total synthesis

CLC Number:

O624.32

TrendMD:

ZHANG Ying-Peng, LI Ying, XUE JI-Jun, NIU Ying-Hui, WU Jiang . Total Syntheses of (±)-3,5-Dihydroxy-7,4′-dimethoxy-dihydroflavonol and (±)-3,5,7-Trihydroxy-4′-methoxy-dihydroflavonol[J]. Chem. J. Chinese Universities, 2004, 25(2): 292.

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Total Syntheses of (±)-3,5-Dihydroxy-7,4′-dimethoxy-dihydroflavonol and (±)-3,5,7-Trihydroxy-4′-methoxy-dihydroflavonol

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