Interaction Between DNA and Terbium(Ⅲ)-Ciprofloxacin Fluorescence Complex and New Tissue Staining Method

Abstract

Abstract: A new lanthanide complex that gives off green fluorescence upon exciting by UV radiation was synthesized by using terbium chloride and ciprofloxacin. The complex binds firmly on DNA and induces conformation changes of DNA based on the analysis of FTIR and fluorescence spectra. Strong fluorescence from terbium ions can be observed from the resultant composite under UV light. Thus, it is possible that the terbium ciprofloxacin complex can be developed as a fluorescent dye in biological and pathological studies. The results indicate that the complex is concentrated on the nuclei regions in the sections of oral tissues and the nuclei are highlighted under fluorescent microscope.

Key words: Rare-earth complex, Ciprofloxacin, Quinolone, Fluorescence, Tissue staining

CLC Number:

O657.31

TrendMD:

YANG Jun, REN Yu, XU Yi-Zhuang, SU Yun-Lan, ZHANG Li, LIU Zhi, WANG Fan, YANG Li-Min, WANG Jing, GAO Hong-Cheng, YE Fang, WU Jin-Guang . Interaction Between DNA and Terbium(Ⅲ)-Ciprofloxacin Fluorescence Complex and New Tissue Staining Method[J]. Chem. J. Chinese Universities, 2004, 25(2): 243.

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Interaction Between DNA and Terbium(Ⅲ)-Ciprofloxacin Fluorescence Complex and New Tissue Staining Method

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