Enantioselective Synthesis of a Natural 8-O-4′ Neolignan Compound

Abstract

Abstract: An enantioselective synthesis approach to erythro 8-O-4′ neolignans was reported. In this route a chiral six-membered cyclic acetal was a key intermediate that was obtained from Sharpless AD reaction followed by change of acetals. Then the stereoselective coupling between the intermediate and phenols by Mitsunobu reaction formed the frame of 8-O-4′ lignans. A natural 8-O-4′ norneolignan was enantioselectively synthesized as a single isomer for the first time by the route.

Key words: 8-O-4&prime, Neolignans, Lignans, Enantioselectivity, Synthesis

CLC Number:

O624.32

TrendMD:

CHEN Xiao-Chuan, REN Xin-Feng, PENG Kun, WU Tong-Xing, PAN Xin-Fu . Enantioselective Synthesis of a Natural 8-O-4′ Neolignan Compound[J]. Chem. J. Chinese Universities, 2004, 25(1): 82.

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Enantioselective Synthesis of a Natural 8-O-4′ Neolignan Compound

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