Synthesis and Characterization of 2-Chloro-2-oxo-1,3,2-dioxaphospholanes Containing Hydroxyl Group and Corresponding Phosphorylcholines

Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (6): 1034.

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Synthesis and Characterization of 2-Chloro-2-oxo-1,3,2-dioxaphospholanes Containing Hydroxyl Group and Corresponding Phosphorylcholines

WANG Ling, YANG Zhi-Mou, CHEN Lin, XU Jian-Min, SHEN Jian, LIN Si-Cong

Research Center of Surface & Interface Chemistry and Engineering Technology, Nanjing University, Nanjing 210093, China

Received:2002-06-06 Online:2003-06-24 Published:2003-06-24

Abstract

Abstract: In order to construct the zwitterionic structure of phosphorylcholine onto the surface of biomaterials, five novel phospholanes containing hydroxyl group were synthesized from the corresponding diol and 2-chloro-2-oxo-1,3,2-dioxaphospholane in the presence of THF. Then, five novel phosphorylcholines containing hydroxyl group were prepared by the corresponding phospholane and anhydrous trimethylamine in the presence of acetonitrile. Their structures were characterized by FTIR, ¹HNMR and elemental analysis.

Key words: Hydroxylated phosphorylcholine, Nonthrombogenic biomaterials, Antithrombogenic biomaterials, Zwitterionic monomer, Zwitterionic nonthrombogenic biomaterials

CLC Number:

O623.627

TrendMD:

WANG Ling, YANG Zhi-Mou, CHEN Lin, XU Jian-Min, SHEN Jian, LIN Si-Cong . Synthesis and Characterization of 2-Chloro-2-oxo-1,3,2-dioxaphospholanes Containing Hydroxyl Group and Corresponding Phosphorylcholines[J]. Chem. J. Chinese Universities, 2003, 24(6): 1034.

Synthesis and Characterization of 2-Chloro-2-oxo-1,3,2-dioxaphospholanes Containing Hydroxyl Group and Corresponding Phosphorylcholines

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