Isolation and Identification of a Novel Cembrane-type Diterpenoid from the Soft Coral Sarcophyton crassocaule

Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (6): 1023.

• Preface • Previous Articles Next Articles

Isolation and Identification of a Novel Cembrane-type Diterpenoid from the Soft Coral Sarcophyton crassocaule

XU Xiao-Hua¹, KONG Chui-Hua², LIN Chang-Jiang¹, WANG Xin¹, LU Jian-Hua¹

1. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China;
2. Institute of Ecology, South China Agricultural University, Guangzhou 510642, China

Received:2002-05-13 Online:2003-06-24 Published:2003-06-24

Abstract

Abstract: A novel cembrane-type diterpenoid was first isolated from the soft coral Sarcophyton crassocaule collected from the Xisha Islands in the South China Sea. Its structure was determined on 2D-NMR, HRMASS and IR techniques and the relative configuration was confirmed by NOESY and X-ray diffraction. The crystaLIs monoclinic, space group P2₁ with cell dimensions of a=0.890 00(10) nm, b=0.638 0(10) nm, c=1.169 670(2) nm. α=90°, β=92.470(10)°, γ=90°, V=0.926(3) nm³, D=1.192 4 g/cm³, Z=2, R=0.057 8, ^wR=0.138 0. The new compound was named as Sarcocrassolide B. It exhibited a strong cytotoxicity against P388 cell line with IC₅₀ value of 1.5 μg/mL.

Key words: Soft coral, Sarcophyton crassocaule, Sarcocrassolide B

CLC Number:

O657

TrendMD:

XU Xiao-Hua, KONG Chui-Hua, LIN Chang-Jiang, WANG Xin, LU Jian-Hua . Isolation and Identification of a Novel Cembrane-type Diterpenoid from the Soft Coral Sarcophyton crassocaule[J]. Chem. J. Chinese Universities, 2003, 24(6): 1023.

[1]	ZHANG Cui-Xian^1,2, YAN Su-Jun¹, ZHANG Guang-Wen³, SU Jing-Yu¹, ZENG Long-Mei¹. Isolation of New Polyhydroxylated Sterol from Soft Coral Sarcophyton crassocaule* Mosre [J]. Chem. J. Chinese Universities, 2007, 28(4): 686.
[2]	ZHANG Guang-Wen, MA Xiang-Quan, YAN Su-Jun, ZENG Long-Mei, SU Jing-Yu. Two New Steroidal Saponins from the Soft Coral Cladiella sp. [J]. Chem. J. Chinese Universities, 2005, 26(1): 81.
[3]	MA Xiang-Quan, YAN Su-Jun, SU Jing-Yu, ZENG Long-Mei . Separation and Structural Determination of Structure of a New Cembranoid Lactone from the Soft Coral of Sarcophyton sp. [J]. Chem. J. Chinese Universities, 2004, 25(3): 479.
[4]	LAN Wen-Jian, LIN Cui-Wu, SU Jing-Yu, ZENG Long-Mei. Two Steroidal Glycosides from the Soft Coral Cladiella krempfi [J]. Chem. J. Chinese Universities, 2003, 24(11): 2019.
[5]	HE Xi-Xin, SU Jing-Yu, ZENG Long-Mei, YANG Ruo-Lin. A New Glycoside, Cervicoside, from the Soft Coral Sinularia Cervicornis Tix-Dur [J]. Chem. J. Chinese Universities, 2002, 23(8): 1536.
[6]	SU Jing-Yu, YAN Su-Jun, ZENG Long-Mei . A New Diterpene Lactone from the Soft Coral Sarcophyton molle Tix. Dur. [J]. Chem. J. Chinese Universities, 2001, 22(9): 1515.
[7]	WANG Guiyang-sheng, LI Feng-ying, ZENG Long-mei, MA Li-bin, TU Guang-zhong. Structure Determination of Nephalsterol A and B with 19-hydroxy Group from Soft Corals Nephthea [J]. Chem. J. Chinese Universities, 1992, 13(5): 623.
[8]	ZENG Long-mei, WANG Guiyang-shen, MA Li-bin, TU Guang-zhong. Studies on the Chemical Structure of Nephalsterol-B [J]. Chem. J. Chinese Universities, 1992, 13(3): 341.
[9]	LIU Ji-kai, ZENG Long-mei, WU Da-gang . A New Sterol from the Marine Soft Coral Nephthea Sinulata [J]. Chem. J. Chinese Universities, 1992, 13(3): 355.
[10]	SU Jing-Yu, MENG Yan-Hui, ZENG Long-Mei, WANG Qi-Wen. A Novel Secondary Metabolite from the Soft Coral Lobophytum Caledonense [J]. Chem. J. Chinese Universities, 1992, 13(12): 1546.
[11]	Zeng Long-mei, Wang Guiyangsheng, Li Feng-ying, Zhong Yong-li . 24-Methylene-Cholestane-3β,5α,6β,19-tetraol--a Novel Polyhydroxylated Sterol with Rare 19-Hydroxyl Group [J]. Chem. J. Chinese Universities, 1991, 12(7): 910.
[12]	Su Jing-yu, Zhong Yong-li, Zeng Long-mei . Structure Determination of a Novel Sterol--Clavisterol A [J]. Chem. J. Chinese Universities, 1991, 12(1): 49.

Isolation and Identification of a Novel Cembrane-type Diterpenoid from the Soft Coral Sarcophyton crassocaule

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 12

Recommended Articles

Metrics

Comments