Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (5): 843.

• Articles • Previous Articles     Next Articles

Total Synthesis of Natural Macrocyclic Diterpene(±)-Mayol

LI Shu-Hua, PENG Li-Zeng, ZHANG Tao, LI Yu-Lin   

  1. National Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:2002-04-08 Online:2003-05-24 Published:2003-05-24

Abstract: Afacile and efficient total synthesis of (±)-mayol starting from gcraniol has been carried out in 10 steps. The key steps are the alkylation reaction of allylic iodide 3 with phenyl sulfone 4 and the chromium-induced intramolecular macrocyclization of allylic chloride and aldehyde.

Key words: Cembrane-type macrocyclic diterpcne, Natural product, Total synthesis, (±)-Mayol

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