CJCU

Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (4): 636.

• Preface • Previous Articles     Next Articles

In vitro Studies on the Immunoadsorbent for Removal of IgA in IgA-Nephropathy (Ⅱ)

CHU Jia Qiang1, YU Yao Ting1, ZHANG Wei Hua1, CHEN Jian Jun1, ZHU Bo Ru1, LIU Jing Duo2   

  1. 1. Key Lab of Bioactive Materials Research of Educational Ministry, Nankai University, Tianjin 300071;
    2. Air Force Military General Hospital, Beijng 100035, China
  • Received:2002-03-12 Online:2003-04-24 Published:2003-04-24

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Abstract: Bead type agarose as a carrier was prepared and activated by glycidyl 1,4 butanediol which could easily couple with human IgG because it has a long spacer, thus reducing the hinderence effect of IgG coupling reaction. In vitro experiments showed that the immunoadsorbent could adsorb 60% of IgA in plasma which is much higher than the CDI coupling method of 35%.

Key words: IgA nephropathy, Autoimmune disease, Immunoadsorbent

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