CJCU

Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (10): 1775.

• Articles • Previous Articles     Next Articles

Enhancement of Signal-to-Noise Ratio in Chip-based Capillary Electrophoresis Systems by a Hadamard Transform Approach

ZHANG Tao1, FANG Qun2, FANG Zhao-Lun1,2   

  1. 1. Research Center for Analytical Sciences, Northeastern University, Shenyang 110006, China;
    2. Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310028, China
  • Received:2002-11-26 Online:2003-10-24 Published:2003-10-24

PDF (PC)

Abstract: The first demonstration of Hadamard transform capillary electrophoresis(CE) is reported for enhancing the signal-to-noise ratios(S/N) on a microfluidic chip using a simple electrokinetically gated injection approach in this paper.Sample or running buffer was alternatively injected into the separation channel according to a 7-bit, 127-step pseudorandom binary sequence(PRBS).The electrophoregram rebuilt from detector signal with inverse Hadamard transform improved the S/Nratio by a factor of 5(5.6 in theory), compared to conventional single injection electrophoregram, almost without affecting the sample throughput.

Key words: Microfluidic control analysis system, Chip-based capillary electrophoresis, Hadamard transform, Signal-to-noise ratio, Digital signal processing

CLC Number: 

TrendMD: