Chem. J. Chinese Universities ›› 2003, Vol. 24 ›› Issue (1): 64.
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JIANG Zong-Lin, XIAO Rong, SU Xiao-Yu, YAN Jia-Ming, XIE Ru-Gang
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Abstract: A novel and selective one-pot synthetic method of imidazole and benzimidazole derivatives has been developed. Three series of target compounds, 1-(ω-haloalkyl) imidazoles 3a-3e, bis-imidazoles 5a-5b and tri-imidazoles 6a-6b have been synthesized by the selective quaterisation of 1H-imidazole-1-propanenitrile (1) with α, ω-dihalide, bis(bromomethyl) benzene or tri(bromomethyl) benzene to obtain imidazolium salts, following by Hoffmann-type elimination. Similarly, benzimidazole analogues 7 and 8 were also prepared. It is found that important factors affecting this selective quaterisation are the solvent, temperature, structure and amount of halides.
Key words: Imidazole derivative, Quaterisation, Hoffmann-type elimination
CLC Number:
O621
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JIANG Zong-Lin, XIAO Rong, SU Xiao-Yu, YAN Jia-Ming, XIE Ru-Gang. Selective One-pot Synthetic Method for Imidazole and Benzimidazole Derivatives[J]. Chem. J. Chinese Universities, 2003, 24(1): 64.
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http://www.cjcu.jlu.edu.cn/EN/Y2003/V24/I1/64
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