Abstract: The inclusion complexation behavior of 6,6′-trimethylenediseleno bridged bis(β-cyclodextrin)(1) and 6,6′-(o-phenylenediseleno) bridged bis(β-cyclodextrin)(2) with dye molecules was investigated by means of fluorescence and ultraviolet spectrometric titrations at 25℃ in phosphate buffer solution(pH 7.20). The results obtained indicated that bis(β-cyclodextrin)s could not only significantly enhance the original binding ability of parent β-cyclodextrin, but also be used to recognize the structural difference of guest molecules through the cooperative binding of the closely located two cyclodextrin cavities. This phenomenon was discussed from the viewpoint of size fit concept and multiple recognition mechanism between the host and guest.

Key words: Bis(β-cyclodextrin), Supramolecular complex, Cooperative binding, Multiple recognition