Synthesis and ESR Study of a Novel Phosphorylated Lipophilic Spin-trap

Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (2): 333.

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Synthesis and ESR Study of a Novel Phosphorylated Lipophilic Spin-trap

XU Ying-Kai, CHEN Zhong-Wei, SUN Jian, LIU Ke, CHEN Wei, SHI Wei, WANG Hong-Mei, ZHANG Xing-Kang, LIU Yang

State Key Lab for Structural Chemistry of Unstable and Stable Species, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China

Received:2001-09-30 Online:2002-02-24 Published:2002-02-24

Abstract

Abstract: Synthesis of a novel α-phosphorus containing spin-trap, DEPPEPO[5-(diethoxyphosphoryl)-5-phenylethyl-1-pyrroline] N-oxide and evaluation of its ability to spin trap the hydroxyl and the superoxide anion radicals were described in the present article. The ability for trapping an active superoxide anion radicals generated in the HX/XO system and the stability of their spin adduct of DEPPEPO were analyzed. In addition, the effects of 5-phenylethyl and 5-phenyl substituted analogues of DMPO on the stereochemistry of the corresponding spin adducts were systematically illustrated.

Key words: Spin trap, Nitrone, Electron-spin Resonance(ESR), Superoxide anion

CLC Number:

O623.71⁺5

TrendMD:

XU Ying-Kai, CHEN Zhong-Wei, SUN Jian, LIU Ke, CHEN Wei, SHI Wei, WANG Hong-Mei, ZHANG Xing-Kang, LIU Yang. Synthesis and ESR Study of a Novel Phosphorylated Lipophilic Spin-trap[J]. Chem. J. Chinese Universities, 2002, 23(2): 333.

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Synthesis and ESR Study of a Novel Phosphorylated Lipophilic Spin-trap

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