Abstract: Myasthenia Gravis(MG) is an serious nerval specific autoimmune disease. The pathogenic factor of the disease is the anti-AChR antibodies in the blood of patients which react against the acetylcholine receptor(AChR). Literature reported that the AChR ab could be adsorbed by adsorbent linked with special amino acids or proteins. In order to remove AChr ab from blood, we studied the selectivity and adsorption capacity of various ligands and matrixes. Experimental results showed that immunoadsorbent prepared by coupling L-tryptophan to epichlorohydrin-activated cellulose bead(6%) gave the best result. Adsorbent of 1.0 g in 3.0 mL of serum could remove 25% of antibody from the serum, which will have a high potential application in the future.

Key words: Myasthenia Gravis, AChR ab, Immunoadsorbent