CJCU

Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (10): 1882.

• Articles • Previous Articles     Next Articles

Synthesis and Biological Activities of Imidazolo[2,1-b]-1,3,4-thiadiazole,S-Triazole[3,4-b]-1,3,4-thiadiazole Derivatives Bearing 1H-1,2,4-triazole

ZHANG Yan1, LIU Dong1, DAI Chao-Feng1, ZHANG Zi-Yi1, XU Peng-Fei1, HUI Xin-Ping1, WANG Qin2   

  1. 1. National Laboratory of Applied Organic Chemistry, College of Chemistry and Engineering, Lanzhou University;
    2. College of Lif e Science, Lanzhou University, Lanzhou 730000, China
  • Received:2001-07-17 Online:2002-10-24 Published:2002-10-24

PDF (PC)

Cited

42

Abstract: Eighteen novel imidazolo-1,3,4-thiadiazoles and S-triazole-1,3,4-thiadiazoles containing 1H-1,2,4-triazole were synthesized and their structures were confirmed by elemental analyses and spectral analysis. And the characteristic data of 1H NMR and MS were explained reasonably. Furthermore, we also proposed the synthetic mechanism of 2,5,6-substituted-imidazolo-1,3,4-thiadiazole. Primary antibacterial test against E.coli, P.aeruginosa, B.subtilis and S.aureus showed that most of them had good antibacterial activities.

Key words: 1H-1,2,4-Triazole, Imidazolo[2,1-b]-1,3,4-thiadiazole, S-triazole[3,4-b]-1,3,4-thiadiazole, Antibacterial activities

CLC Number: 

TrendMD: