Studies on the Synthesis, Relaxivity and Liver-targeting of DTPA-Pyridoxol Ester Gadolinium Complexes

Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (1): 49.

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Studies on the Synthesis, Relaxivity and Liver-targeting of DTPA-Pyridoxol Ester Gadolinium Complexes

DING Xiong-Jun, ZHUO Ren-Xi, FU Gong-Cheng

Key Laboratory of Biomedical Polymer Materials, Ministry of Education; Department of Chemistry, Wuhan University, Wuhan 430072, China

Received:2000-11-11 Online:2002-01-24 Published:2002-01-24

Abstract

Abstract: Several new DTPA-pyridoxol ester ligands were synthesized by reacting diethylene-triam inepentaacetic anhydride(DTPAA) with pyridoxol derivatives. Their gadolinium complexes were also prepared. Their T₁ relaxivities in water were measured. The ⁹⁹Tc-labelled combination radioactivity experiment with liver cells and kidney cells of mice showed that ligands 2 and 6 possessed an excellent liver-targeting property. The results of animal MR imaging experiment further confirmed that the signals in liver were obviously strengthened after injection of Gd2 and Gd6.

Key words: MRI contrast agent, Pyridoxol, Liver targeting, Godolinium complex, Relaxivity

CLC Number:

O621.21

TrendMD:

DING Xiong-Jun, ZHUO Ren-Xi, FU Gong-Cheng . Studies on the Synthesis, Relaxivity and Liver-targeting of DTPA-Pyridoxol Ester Gadolinium Complexes[J]. Chem. J. Chinese Universities, 2002, 23(1): 49.

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Studies on the Synthesis, Relaxivity and Liver-targeting of DTPA-Pyridoxol Ester Gadolinium Complexes

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